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Target
Heme oxygenase 1
Ligand
BDBM8610
Substrate
n/a
Meas. Tech.
ChEMBL_1901234 (CHEMBL4403456)
IC50
300±n/a nM
Citation
 Intagliata, S; Salerno, L; Ciaffaglione, V; Leonardi, C; Fallica, AN; Carota, G; Amata, E; Marrazzo, A; Pittalà, V; Romeo, G Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors. Eur J Med Chem 183:0 (2019) [PubMed]  Article 
Target
Name:
Heme oxygenase 1
Synonyms:
HSP32 | HMOX1_RAT | Hmox1 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1
Type:
Enzyme
Mol. Mass.:
33005.15
Organism:
Rat
Description:
HO-1 obtained from rat spleen was used in enzyme assays.
Residue:
289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
  
Inhibitor
Name:
BDBM8610
Synonyms:
24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one | CHEMBL75 | Ketoconazole | US9138393, Ketoconozole | US9144538, Ketoconozole
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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