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Target
Bromodomain testis-specific protein
Ligand
BDBM50103503
Substrate
n/a
Meas. Tech.
ChEMBL_1903714 (CHEMBL4405936)
Kd
708±n/a nM
Citation
 Liu, Z; Chen, H; Wang, P; Li, Y; Wold, EA; Leonard, PG; Joseph, S; Brasier, AR; Tian, B; Zhou, J Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation. J Med Chem 63:5242-5256 (2020) [PubMed]  Article 
Target
Name:
Bromodomain testis-specific protein
Synonyms:
Cancer/testis antigen 9 | CT9 | RING3-like protein | BRDT_HUMAN | BRDT | Bromodomain and extra-terminal motif (BET)
Type:
PROTEIN
Mol. Mass.:
107982.01
Organism:
Human
Description:
ChEMBL_1502985
Residue:
947
Sequence:
MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSVFPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRLKEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECIPPEGRTGVTQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGDSDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKARTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQDKSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD
  
Inhibitor
Name:
BDBM50103503
Synonyms:
CHEMBL2393130 | US11117865, Compound RVX-208 | US20250221977, Compound RVX-208
Type:
Small organic molecule
Emp. Form.:
C20H22N2O5
Mol. Mass.:
370.15
SMILES:
Cc1cc(cc(c1OCCO)C)C2=Nc3cc(cc(c3C(=O)N2)OC)OC
Structure:
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