Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50085874
Substrate
n/a
Meas. Tech.
ChEMBL_72360 (CHEMBL686597)
IC50
8±n/a nM
Citation
 Gao, Y; Luo, J; Yao, ZJ; Guo, R; Zou, H; Kelley, J; Voigt, JH; Yang, D; Burke, TR Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic. J Med Chem 43:911-20 (2000) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50085874
Synonyms:
2-{4-[(S)-2-(1-{(S)-2-Carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-2-(oxalyl-amino)-ethyl]-phenyl}-malonic acid | 2-{4-[2-(1-{2-Carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-2-(oxalyl-amino)-ethyl]-phenyl}-malonic acid | CHEMBL279961
Type:
Small organic molecule
Emp. Form.:
C37H44N6O11
Mol. Mass.:
748.7789
SMILES:
Cc1ccc2n(CCCNC(=O)[C@H](CC(N)=O)NC(=O)C3(CCCCC3)NC(=O)[C@H](Cc3ccc(cc3)C(C(O)=O)C(O)=O)NC(=O)C(O)=O)ccc2c1
Structure:
Search PDB for entries with ligand similarity: