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Target
Casein kinase I
Ligand
BDBM50530637
Substrate
n/a
Meas. Tech.
ChEMBL_1913623 (CHEMBL4416206)
Kd
150±n/a nM
Citation
 Matralis, AN; Malik, A; Penzo, M; Moreno, I; Almela, MJ; Camino, I; Crespo, B; Saadeddin, A; Ghidelli-Disse, S; Rueda, L; Calderon, F; Osborne, SA; Drewes, G; Böesche, M; Fernández-Álvaro, E; Martin Hernando, JI; Baker, DA Development of Chemical Entities Endowed with Potent Fast-Killing Properties against  J Med Chem 62:9217-9235 (2019) [PubMed]  Article 
Target
Name:
Casein kinase I
Synonyms:
2.7.11.1 | Casein kinase I | KC1_PLAF7 | CK1
Type:
PROTEIN
Mol. Mass.:
37646.71
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_119141
Residue:
323
Sequence:
MEIRVANKYALGKKLGSGSFGDIYVAKDIVTMEEFAVKLESTRSKHPQLLYESKLYKILGGGIGVPKVYWYGIEGDFTIMVLDLLGPSLEDLFTLCNRKFSLKTVLMTADQMLNRIEYVHSKNFIHRDIKPDNFLIGRGKKVTLIHIIDFGLAKKYRDSRSHTHIPYKEGKNLTGTARYASINTHLGIEQSRRDDIEALGYVLMYFLRGSLPWQGLKAISKKDKYDKIMEKKISTSVEVLCRNASFEFVTYLNYCRSLRFEDRPDYTYLRRLLKDLFIREGFTYDFLFDWTCVYASEKDKKKMLENKNRFDQTADQEGRVKQN
  
Inhibitor
Name:
BDBM50530637
Synonyms:
CHEMBL4591417
Type:
Small organic molecule
Emp. Form.:
C24H23FN6S
Mol. Mass.:
446.56
SMILES:
Cc1cc(Nc2nccc(n2)-c2sc(nc2-c2ccc(F)cc2)C2CCNCC2)ccn1
Structure:
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