Reaction Details Report a problem with these data
Target
Calcium-dependent protein kinase 1
Ligand
BDBM50530659
Substrate
n/a
Meas. Tech.
ChEMBL_1913619 (CHEMBL4416202)
Kd
2100±n/a nM
Citation
 Matralis, AN; Malik, A; Penzo, M; Moreno, I; Almela, MJ; Camino, I; Crespo, B; Saadeddin, A; Ghidelli-Disse, S; Rueda, L; Calderon, F; Osborne, SA; Drewes, G; Böesche, M; Fernández-Álvaro, E; Martin Hernando, JI; Baker, DA Development of Chemical Entities Endowed with Potent Fast-Killing Properties against  J Med Chem 62:9217-9235 (2019) [PubMed]  Article 
Target
Name:
Calcium-dependent protein kinase 1
Synonyms:
Calcium-dependent protein kinase 1 | PfCDPK1 | CDPK1_PLAFK | CDPK1 | CPK1
Type:
PROTEIN
Mol. Mass.:
60804.87
Organism:
Plasmodium Falciparum
Description:
P62343
Residue:
524
Sequence:
MGCSQSSNVKDFKTRRSKFTNGNNYGKSGNNKNSEDLAINPGMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCREKHGHGEKAIKVIKKSQFDKMKYSITNKIECDDKIHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKHSLLNIKIVDFGLSSFFSKDNKLRDRLGTAYYIAPEVLRKKYNEKCDVWSCGVILYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISEEAKELIKLMLTYDYNKRITAKEALNSKWIKKYANNINKSDQKTLCGALSNMRKFEGSQKLAQAAILFIGSKLTTLEERKELTDIFKKLDKNGDGQLDKKELIEGYNILRSFKNELGELKNVEEEVDNILKEVDFDKNGYIEYSEFISVCMDKQILFSEERLRDAFNLFDTDKSGKITKEELANLFGLTSISEQMWNEVLGEADKNKDNMIDFDEFVNMMHKICDNKSS
  
Inhibitor
Name:
BDBM50530659
Synonyms:
CHEMBL4461850
Type:
Small organic molecule
Emp. Form.:
C24H29FN6S2
Mol. Mass.:
484.67
SMILES:
Fc1ccc(cc1)-c1nc(sc1-c1ccnc(NCCN2CCSCC2)n1)C1CCNCC1
Structure:
Search PDB for entries with ligand similarity: