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Target
Thymidine phosphorylase
Ligand
BDBM50531739
Substrate
n/a
Meas. Tech.
ChEMBL_1920784 (CHEMBL4423629)
IC50
35±n/a nM
Citation
 de Moura Sperotto, ND; Deves Roth, C; Rodrigues-Junior, VS; Ev Neves, C; Reisdorfer Paula, F; da Silva Dadda, A; Bergo, P; Freitas de Freitas, T; Souza Macchi, F; Moura, S; Duarte de Souza, AP; Campos, MM; Valim Bizarro, C; Santos, DS; Basso, LA; Machado, P Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in Vitro Toxicity, and Impact on Human Glioblastoma Cancer. J Med Chem 62:1231-1245 (2019) [PubMed]  Article 
Target
Name:
Thymidine phosphorylase
Synonyms:
TdRPase | PD-ECGF | Gliostatin | Platelet-derived endothelial cell growth factor | TP | TYPH_HUMAN | TYMP | ECGF1 | Thymidine phosphorylase | Thymidine Phosphorylase (TP)
Type:
Enzyme
Mol. Mass.:
49948.87
Organism:
Human
Description:
The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319).
Residue:
482
Sequence:
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ
  
Inhibitor
Name:
BDBM50531739
Synonyms:
MA-1 | TPI (freebase) | Tipiracil
Type:
Small organic molecule
Emp. Form.:
C9H11ClN4O2
Mol. Mass.:
242.67
SMILES:
Oc1nc(O)c(Cl)c(CN2CCCC2=N)n1
Structure:
Search PDB for entries with ligand similarity: