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Target
Cytosol aminopeptidase
Ligand
BDBM50534071
Substrate
n/a
Meas. Tech.
ChEMBL_1927716 (CHEMBL4430788)
IC50
379400±n/a nM
Citation
 Ziemska, J; Guśpiel, A; Jarosz, J; Nasulewicz-Goldeman, A; Wietrzyk, J; Kawęcki, R; Pypowski, K; Jarończyk, M; Solecka, J Molecular docking studies, biological and toxicity evaluation of dihydroisoquinoline derivatives as potential anticancer agents. Bioorg Med Chem 24:5302-5314 (2016) [PubMed]  Article 
Target
Name:
Cytosol aminopeptidase
Synonyms:
AMPL_PIG | LAP3 | 3.4.11.1 | 3.4.11.5 | 3.4.13.23 | Cysteinylglycine-S-conjugate dipeptidase | LAP-3 | Leucine aminopeptidase 3 | Leucyl aminopeptidase | Proline aminopeptidase | Prolyl aminopeptidase
Type:
PROTEIN
Mol. Mass.:
56047.39
Organism:
Pig
Description:
ChEMBL_101481
Residue:
519
Sequence:
MFLLPLPAAARVAVRQLSVRRFWGPGPDAANMTKGLVLGIYSKEKEDDAPQFTSAGENFDKLVSGKLREILNISGPPLKAGKTRTFYGLHEDFSSVVVVGLGKKGAGVDDQENWHEGKENIRAAVAAGCRQIQDLEIPSVEVDPCGDAQAAAEGAVLGLYEYDELKQKKKVVVSAKLHGSGDQEAWQRGVLFASGQNLARHLMETPANEMTPTRFAEVIEKNLKSASSKTDVHIRPKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYKGSPDASDPPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSTIVSAAKLDLPINLVGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTKQIVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMAGRPTRTLIEFLLRFSQDSA
  
Inhibitor
Name:
BDBM50534071
Synonyms:
CHEMBL4563759
Type:
Small organic molecule
Emp. Form.:
C10H9NO4
Mol. Mass.:
207.19
SMILES:
OC(=O)C1Cc2cc(O)cc(O)c2C=N1 |c:14|
Structure:
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