Reaction Details Report a problem with these data
Target
Adenosine 5'-monophosphoramidase HINT1
Ligand
BDBM50360481
Substrate
n/a
Meas. Tech.
ChEMBL_1929726 (CHEMBL4432902)
IC50
25500±n/a nM
Citation
 Shah, R; Strom, A; Zhou, A; Maize, KM; Finzel, BC; Wagner, CR Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1. ACS Med Chem Lett 7:780-4 (2016) [PubMed]  Article 
Target
Name:
Adenosine 5'-monophosphoramidase HINT1
Synonyms:
Adenosine 5'-monophosphoramidase | PKCI-1 | Protein kinase C-interacting protein 1 | Protein kinase C inhibitor 1 | HINT1_HUMAN | HINT1 | HINT | PKCI1 | PRKCNH1 | Histidine triad nucleotide-binding protein 1
Type:
PROTEIN
Mol. Mass.:
13803.77
Organism:
Human
Description:
ChEMBL_795618
Residue:
126
Sequence:
MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
  
Inhibitor
Name:
BDBM50360481
Synonyms:
CHEMBL1934757
Type:
Small organic molecule
Emp. Form.:
C21H23N7O6
Mol. Mass.:
n/a
SMILES:
Nc1nc2c(ncn2[C@@H]2O[C@H](COC(=O)NCCc3c[nH]c4ccccc34)[C@@H](O)[C@H]2O)c(=O)[nH]1
Structure:
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