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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50535735
Substrate
n/a
Meas. Tech.
ChEMBL_1931086 (CHEMBL4434337)
EC50
1380±n/a nM
Citation
 Choung, W; Yang, D; Kim, H; Choi, H; Lee, BR; Park, M; Jang, SM; Lim, JS; Kim, WS; Kim, KH; Chin, J; Jung, K; Lee, G; Hong, E; Jang, TH; Joo, J; Hwang, H; Myung, J; Kim, SH Discovery of BR102375, a new class of non-TZD PPARĪ³ full agonist for the treatment of type 2 diabetes. Bioorg Med Chem Lett 29:2275-2282 (2019) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Human
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50535735
Synonyms:
CHEMBL4440354
Type:
Small organic molecule
Emp. Form.:
C34H30F2N6O4
Mol. Mass.:
624.65
SMILES:
CCCCc1nc(C)c(Cc2nc(Cc3cc(F)cc(F)c3)no2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1noc(=O)[nH]1
Structure:
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