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Target
Genome polyprotein
Ligand
BDBM50094207
Substrate
n/a
Meas. Tech.
ChEMBL_158970 (CHEMBL766327)
IC50
805000±n/a nM
Citation
 Borthwick, AD; Angier, SJ; Crame, AJ; Exall, AM; Haley, TM; Hart, GJ; Mason, AM; Pennell, AM; Weingarten, GG Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 1. The alpha-methyl-trans-lactam template. J Med Chem 43:4452-64 (2000) [PubMed]  Article 
Target
Name:
Genome polyprotein
Synonyms:
Human rhinovirus B 3A protease | Human rhinovirus A protease
Type:
PROTEIN
Mol. Mass.:
44361.04
Organism:
Human rhinovirus B
Description:
ChEMBL_158953
Residue:
401
Sequence:
AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMSAIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIANIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVITTGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDRNEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQTIHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA
  
Inhibitor
Name:
BDBM50094207
Synonyms:
1-(2-Acetoxy-acetyl)-3-methyl-2-oxo-octahydro-cyclopenta[b]pyrrole-4-carboxylic acid benzyl ester | CHEMBL344584
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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