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Target
Ataxin-3-like protein
Ligand
BDBM50538571
Substrate
n/a
Meas. Tech.
ChEMBL_1973187 (CHEMBL4606005)
IC50
>10000±n/a nM
Citation
 Leger, PR; Hu, DX; Biannic, B; Bui, M; Han, X; Karbarz, E; Maung, J; Okano, A; Osipov, M; Shibuya, GM; Young, K; Higgs, C; Abraham, B; Bradford, D; Cho, C; Colas, C; Jacobson, S; Ohol, YM; Pookot, D; Rana, P; Sanchez, J; Shah, N; Sun, M; Wong, S; Brockstedt, DG; Kassner, PD; Schwarz, JB; Wustrow, DJ Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity. J Med Chem 63:5398-5420 (2020) [PubMed]  Article 
Target
Name:
Ataxin-3-like protein
Synonyms:
3.4.19.12 | Ataxin-3-like protein | Machado-Joseph disease protein 1-like | ATX3L_HUMAN | ATXN3L | ATX3L | MJDL
Type:
PROTEIN
Mol. Mass.:
40728.34
Organism:
Human
Description:
ChEMBL_119948
Residue:
355
Sequence:
MDFIFHEKQEGFLCAQHCLNNLLQGEYFSPVELASIAHQLDEEERMRMAEGGVTSEEYLAFLQQPSENMDDTGFFSIQVISNALKFWGLEIIHFNNPEYQKLGIDPINERSFICNYKQHWFTIRKFGKHWFNLNSLLAGPELISDTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQIISVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQETNREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLHERPTTSSRAIESDLSDDISEGTVQAAVDTILEIMRKNLKIKGEK
  
Inhibitor
Name:
BDBM50538571
Synonyms:
CHEMBL4635160
Type:
Small organic molecule
Emp. Form.:
C28H30ClN3O3S
Mol. Mass.:
524.09
SMILES:
C[C@H]1CNCC[C@H]1Oc1c(C)cc(Cl)cc1-c1ccnc2cc(CN3C(=O)C4C(C3=O)C4(C)C)sc12 |r|
Structure:
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