Reaction Details Report a problem with these data
Target
Eukaryotic initiation factor 4A-I
Ligand
BDBM50080528
Substrate
n/a
Meas. Tech.
ChEMBL_1983227 (CHEMBL4616489)
IC50
142±n/a nM
Citation
 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase. J Med Chem 63:5879-5955 (2020) [PubMed]  Article 
Target
Name:
Eukaryotic initiation factor 4A-I
Synonyms:
ATP-dependent RNA helicase eIF4A-1 | eIF-4A-I | eIF4A-I | IF4A1_HUMAN | EIF4A1 | DDX2A | EIF4A
Type:
PROTEIN
Mol. Mass.:
46146.87
Organism:
Human
Description:
ChEMBL_864983
Residue:
406
Sequence:
MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
  
Inhibitor
Name:
BDBM50080528
Synonyms:
Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide | CHEMBL123292 | cycloheximide | Zykloheximid | cid_6197 | 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione | med.21724, Compound Cycloheximide
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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