Reaction Details Report a problem with these data
Target
Retinoic acid receptor beta
Ligand
BDBM50097820
Substrate
n/a
Meas. Tech.
ChEBML_195651
IC50
53±n/a nM
Citation
 Beard, RL; Klein, ES; Standeven, AM; Escobar, M; Chandraratna, RA Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity. Bioorg Med Chem Lett 11:765-8 (2001) [PubMed]  Article 
Target
Name:
Retinoic acid receptor beta
Synonyms:
HAP | HBV-activated protein | NR1B2 | Nuclear receptor subfamily 1 group B member 2 | RAR-beta | RAR-epsilon | RARB | RARB_HUMAN | Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta | Retinoic acid receptor beta | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50498.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458015
Residue:
455
Sequence:
MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
  
Inhibitor
Name:
BDBM50097820
Synonyms:
4-[(E)-4-(3,3-Dimethyl-6-p-tolyl-cyclohexa-1,5-dienyl)-but-3-en-1-ynyl]-benzoic acid | CHEMBL350485
Type:
Small organic molecule
Emp. Form.:
C26H24O2
Mol. Mass.:
368.4676
SMILES:
Cc1ccc(cc1)C1=CCC(C)(C)C=C1\C=C\C#Cc1ccc(cc1)C(O)=O |c:14,t:8|
Structure:
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