Reaction Details Report a problem with these data
Target
Retinoic acid receptor gamma
Ligand
BDBM50097820
Substrate
n/a
Meas. Tech.
ChEMBL_196316 (CHEMBL806259)
IC50
31±n/a nM
Citation
 Beard, RL; Klein, ES; Standeven, AM; Escobar, M; Chandraratna, RA Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity. Bioorg Med Chem Lett 11:765-8 (2001) [PubMed]  Article 
Target
Name:
Retinoic acid receptor gamma
Synonyms:
NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50345.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458016
Residue:
454
Sequence:
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
  
Inhibitor
Name:
BDBM50097820
Synonyms:
4-[(E)-4-(3,3-Dimethyl-6-p-tolyl-cyclohexa-1,5-dienyl)-but-3-en-1-ynyl]-benzoic acid | CHEMBL350485
Type:
Small organic molecule
Emp. Form.:
C26H24O2
Mol. Mass.:
368.4676
SMILES:
Cc1ccc(cc1)C1=CCC(C)(C)C=C1\C=C\C#Cc1ccc(cc1)C(O)=O |c:14,t:8|
Structure:
Search PDB for entries with ligand similarity: