Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3
Ligand
BDBM50366597
Substrate
n/a
Meas. Tech.
ChEMBL_1984187 (CHEMBL4617593)
IC50
<1000±n/a nM
Citation
 Tahara, T; Watanabe, A; Yutani, M; Yamano, Y; Sagara, M; Nagai, S; Saito, K; Yamashita, M; Ihara, M; Iida, A STAT3 inhibitory activity of naphthoquinones isolated from Tabebuia avellanedae. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) | STAT3_HUMAN | STAT3 | APRF
Type:
Protein
Mol. Mass.:
88064.31
Organism:
Human
Description:
P40763
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
  
Inhibitor
Name:
BDBM50366597
Synonyms:
2-Acetylfuranonaphthoquinone | BBI-608 | Napabucasin
Type:
Small organic molecule
Emp. Form.:
C14H8O4
Mol. Mass.:
240.21
SMILES:
CC(=O)c1cc2c(o1)C(=O)c3ccccc3C2=O
Structure:
Search PDB for entries with ligand similarity: