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Target
Acidic mammalian chitinase
Ligand
BDBM50541939
Substrate
n/a
Meas. Tech.
ChEMBL_1985608 (CHEMBL4619014)
IC50
7.0±n/a nM
Citation
 Andryianau, G; Kowalski, M; Piotrowicz, MC; Rajkiewicz, AA; Dymek, B; Sklepkiewicz, PL; Pluta, E; Stefaniak, F; Czestkowski, W; Olejniczak, S; Mazur, M; Niedziejko, P; Koralewski, R; Matyszewski, K; Gruza, M; Zagozdzon, A; Salamon, M; Rymaszewska, A; Welzer, M; Dzwonek, K; Golab, J; Olczak, J; Bartoszewicz, A; Golebiowski, A Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase. ACS Med Chem Lett 11:1228-1235 (2020) [PubMed]  Article 
Target
Name:
Acidic mammalian chitinase
Synonyms:
AMCase | Acidic mammalian chitinase (AMCase) | CHIA | CHIA_HUMAN | Lung-specific protein TSA1902
Type:
Protein
Mol. Mass.:
52266.66
Organism:
Homo sapiens (Human)
Description:
Q9BZP6
Residue:
476
Sequence:
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
  
Inhibitor
Name:
BDBM50541939
Synonyms:
CHEMBL4648962
Type:
Small organic molecule
Emp. Form.:
C23H26ClFN6O
Mol. Mass.:
456.944
SMILES:
Nc1nc(n[nH]1)N1CCC(CC1)N1Cc2cc(F)ccc2OC[C@@H]1Cc1ccc(Cl)cc1 |r|
Structure:
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