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Target
Dihydrofolate reductase
Ligand
BDBM50043799
Substrate
n/a
Meas. Tech.
ChEMBL_1988113 (CHEMBL4621660)
Ki
880000±n/a nM
Citation
 Duff, MR; Gabel, SA; Pedersen, LC; DeRose, EF; Krahn, JM; Howell, EE; London, RE The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase. J Med Chem 63:8314-8324 (2020) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase | DYR_HUMAN | DHFR
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Human
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50043799
Synonyms:
(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid | (R)-tryptophan | D-TRYPTOPHAN | CHEMBL292303
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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