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Target
Metabotropic glutamate receptor 2
Ligand
BDBM50544625
Substrate
n/a
Meas. Tech.
ChEMBL_1993272 (CHEMBL4627007)
EC50
7.9±n/a nM
Citation
 Poulie, CBM; Liu, N; Jensen, AA; Bunch, L Design, Synthesis, and Pharmacological Characterization of Heterobivalent Ligands for the Putative 5-HT J Med Chem 63:9928-9949 (2020) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 2
Synonyms:
Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 | GRM2_HUMAN | GRM2 | GPRC1B | MGLUR2
Type:
Enzyme
Mol. Mass.:
95584.88
Organism:
Human
Description:
Q14416
Residue:
872
Sequence:
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
  
Inhibitor
Name:
BDBM50544625
Synonyms:
CHEMBL4632373
Type:
Small organic molecule
Emp. Form.:
C22H25ClN4O
Mol. Mass.:
396.92
SMILES:
COc1ccc(cc1)C1CCN(CC1)c1ccn2c(CC3CC3)nnc2c1Cl
Structure:
Search PDB for entries with ligand similarity: