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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50267632
Substrate
n/a
Meas. Tech.
ChEMBL_1993274 (CHEMBL4627009)
IC50
11±n/a nM
Citation
 Poulie, CBM; Liu, N; Jensen, AA; Bunch, L Design, Synthesis, and Pharmacological Characterization of Heterobivalent Ligands for the Putative 5-HT J Med Chem 63:9928-9949 (2020) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
Serotonin receptor 2A | 5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Human
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50267632
Synonyms:
4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluorophenylethyl)-piperidine | CHEMBL489624
Type:
Small organic molecule
Emp. Form.:
C21 H24 F N O3
Mol. Mass.:
357.41856
SMILES:
COc1c(O)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1
Structure:
Search PDB for entries with ligand similarity: