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Target
Baculoviral IAP repeat-containing protein 2
Ligand
BDBM50546196
Substrate
n/a
Meas. Tech.
ChEMBL_2014746 (CHEMBL4668324)
Kd
6.0±n/a nM
Citation
 Hanan, EJ; Liang, J; Wang, X; Blake, RA; Blaquiere, N; Staben, ST Monomeric Targeted Protein Degraders. J Med Chem 63:11330-11361 (2020) [PubMed]  Article 
Target
Name:
Baculoviral IAP repeat-containing protein 2
Synonyms:
Cellular inhibitor of apoptosis 1 | Baculoviral IAP repeat-containing protein 2 (cIAP1) | Inhibitor of apoptosis protein 2 (cIAP1) | BIRC2_HUMAN | BIRC2 | API1 | MIHB | RNF48
Type:
Protein
Mol. Mass.:
69900.47
Organism:
Human
Description:
Q13490
Residue:
618
Sequence:
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS
  
Inhibitor
Name:
BDBM50546196
Synonyms:
CHEMBL2048500 | CHEBI:47922
Type:
Small organic molecule
Emp. Form.:
C33H44N4O5
Mol. Mass.:
576.74
SMILES:
CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(c1ccccc1)c1ccccc1)C(=O)OC |r|
Structure:
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