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Target
Proteinase-activated receptor 1
Ligand
BDBM50105321
Substrate
n/a
Meas. Tech.
ChEBML_209262
IC50
2100±n/a nM
Citation
 Barrow, JC; Nantermet, PG; Selnick, HG; Glass, KL; Ngo, PL; Young, MB; Pellicore, JM; Breslin, MJ; Hutchinson, JH; Freidinger, RM; Condra, C; Karczewski, J; Bednar, RA; Gaul, SL; Stern, A; Gould, R; Connolly, TM Discovery and initial structure-activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists. Bioorg Med Chem Lett 11:2691-6 (2001) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
Coagulation factor II receptor | PAR-1 | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1) | PAR1_HUMAN | F2R | CF2R | PAR1 | TR
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Human
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50105321
Synonyms:
N-(4-{3-Cyclopropyl-3-[(S)-2-(3,4-dichloro-phenyl)-2-hydroxy-ethyl]-ureido}-benzyl)-2,2-dimethyl-propionamide | CHEMBL88513
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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