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Target
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Ligand
BDBM50547789
Substrate
n/a
Meas. Tech.
ChEMBL_2019055 (CHEMBL4672633)
IC50
1290±n/a nM
Citation
 Tresadern, G; Velter, I; Trabanco, AA; Van den Keybus, F; Macdonald, GJ; Somers, MVF; Vanhoof, G; Leonard, PM; Lamers, MBAC; Van Roosbroeck, YEM; Buijnsters, PJJA [1,2,4]Triazolo[1,5- J Med Chem 63:12887-12910 (2020) [PubMed]  Article 
Target
Name:
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Synonyms:
Phosphodiesterase 3A (PDE3A) | Phosphodiesterase Type 3 (PDE3A) | Cyclic GMP-inhibited phosphodiesterase A | cGMP-inhibited 3,5-cyclic phosphodiesterase A | Phosphodiesterase 3A | Phosphodiesterase 3A (PDE3A1) | CGI-PDE A | cGMP-inhibited 3',5'-cyclic phosphodiesterase A | PDE3A_HUMAN | PDE3A | 3',5'-cyclic phosphodiesterase | Phosphodiesterase 3 (PDE3) | Phosphodiesterase 3 | Phosphodiesterase 3 and 5 (PDE3 and PDE5)
Type:
Enzyme
Mol. Mass.:
124966.46
Organism:
Human
Description:
Q14432
Residue:
1141
Sequence:
MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ
  
Inhibitor
Name:
BDBM50547789
Synonyms:
CHEMBL4794209
Type:
Small organic molecule
Emp. Form.:
C21H19F2N5O2
Mol. Mass.:
411.41
SMILES:
C[C@@H]1CCN(C[C@H]1c1cc(nc2ncnn12)C(F)F)C(=O)c1ccc2occc2c1 |r|
Structure:
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