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Target
Histone deacetylase 1
Ligand
BDBM19149
Substrate
n/a
Meas. Tech.
ChEMBL_87865 (CHEMBL697288)
IC50
112±n/a nM
Citation
 Mai, A; Massa, S; Ragno, R; Esposito, M; Sbardella, G; Nocca, G; Scatena, R; Jesacher, F; Loidl, P; Brosch, G Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation. J Med Chem 45:1778-84 (2002) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
HD1 | HDAC1_MOUSE | Hdac1 | Histone deacetylase 1/2
Type:
Protein
Mol. Mass.:
55062.26
Organism:
Mouse
Description:
O09106
Residue:
482
Sequence:
MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM19149
Synonyms:
Zolinza | suberoylanilide hydroxamic acid | CHEMBL98 | cid_5311 | N-hydroxy-N'-phenyloctanediamide | Vorinostat | SAHA | US9115116, SAHA | US9695181, Vorinostat | US9428447, SAHA | US9353061, SAHA | US10188756, Compound SAHA | US10011611, SAHA | US11207431, SAHA | US11505523, Compound SAHA | US20240327418, Example SAHA
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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