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Target
Methionine--tRNA ligase, mitochondrial
Ligand
BDBM50553189
Substrate
n/a
Meas. Tech.
ChEMBL_2045379 (CHEMBL4700078)
EC50
75±n/a nM
Citation
 Zhang, Z; Barros-Álvarez, X; Gillespie, JR; Ranade, RM; Huang, W; Shibata, S; Molasky, NMR; Faghih, O; Mushtaq, A; Choy, RKM; de Hostos, E; Hol, WGJ; Verlinde, CLMJ; Buckner, FS; Fan, E Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against  RSC Med Chem 11:885-895 (2020) [PubMed]  Article 
Target
Name:
Methionine--tRNA ligase, mitochondrial
Synonyms:
SYMM_HUMAN | MARS2 | 6.1.1.10 | Methionine--tRNA ligase, mitochondrial | Methionyl-tRNA synthetase 2 | Mitochondrial methionyl-tRNA synthetase | MtMetRS
Type:
PROTEIN
Mol. Mass.:
66605.24
Organism:
Human
Description:
ChEMBL_120165
Residue:
593
Sequence:
MLRTSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHIGHLYSALLADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQFQQLFQEAGISCTDFIRTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEAKVTQQPGPSGDSFPVSLESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITPEPFHHVVLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNAEFKSWWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADHYDNFRIYKALEAVSSCVRQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTLLQPVTPSLADKLLSRLGVSASERSLGELYFLPRFYGHPCPFEGRRLGPETGLLFPRLDQSRTWLVKAHRT
  
Inhibitor
Name:
BDBM50553189
Synonyms:
CHEMBL4762630
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: