Reaction Details
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Chitotriosidase-1
Ligand
BDBM50554342
Substrate
n/a
Meas. Tech.
ChEMBL_2049316 (CHEMBL4704015)
IC50
14±n/a nM
Citation
Koralewski, R; Dymek, B; Mazur, M; Sklepkiewicz, P; Olejniczak, S; Czestkowski, W; Matyszewski, K; Andryianau, G; Niedziejko, P; Kowalski, M; Gruza, M; Borek, B; Jedrzejczak, K; Bartoszewicz, A; Pluta, E; Rymaszewska, A; Kania, M; Rejczak, T; Piasecka, S; Mlacki, M; Mazurkiewicz, M; Piotrowicz, M; Salamon, M; Zagozdzon, A; Napiorkowska-Gromadzka, A; Bartlomiejczak, A; Mozga, W; Dobrzański, P; Dzwonek, K; Golab, J; Nowotny, M; Olczak, J; Golebiowski, A Discovery of J Med Chem 63:15527-15540 (2020) [PubMed] Article More Info.:
Target
Name:
Chitotriosidase-1
Synonyms:
3.2.1.14 | Chitinase-1 | Chitotriosidase-1 | CHIT1_MOUSE | Chit1
Type:
PROTEIN
Mol. Mass.:
51108.04
Organism:
Mouse
Description:
ChEMBL_117450
Residue:
464
Sequence:
MVQSLAWAGVMTLLMVQWGSAAKLVCYLTNWSQYRTEAVRFFPRDVDPNLCTHVIFAFAGMDNHQLSTVEHNDELLYQELNSLKTKNPKLKTLLAVGGWTFGTQKFTDMVATASNRQTFVKSALSFLRTQGFDGLDLDWEFPGGRGSPTVDKERFTALIQDLAKAFQEEAQSSGKERLLLTAAVPSDRGLVDAGYEVDKIAQSLDFINLMAYDFHSSLEKTTGHNSPLYKRQGESGAAAEQNVDAAVTLWLQKGTPASKLILGMPTYGRSFTLASSSDNGVGAPATGPGAPGPYTKDKGVLAYYEACSWKERHRIEDQKVPYAFQDNQWVSFDDVESFKAKAAYLKQKGLGGAMVWVLDLDDFKGSFCNQGPYPLIRTLRQELNLPSETPRSPEQIIPEPRPSSMPEQGPSPGLDNFCQGKADGVYPNPGDESTYYNCGGGRLFQQSCPPGLVFRASCKCCTWS
Inhibitor
Name:
BDBM50554342
Synonyms:
CHEMBL4776610
Type:
Small organic molecule
Emp. Form.:
C20H29ClN6O
Mol. Mass.:
404.95
SMILES:
CC[C@H]1CN([C@@H](Cc2ccc(Cl)cc2)CO1)C1CCN(CC1)c1nc(N)n[nH]1 |r|
Structure:
