Reaction Details
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Acidic mammalian chitinase
Ligand
BDBM50554340
Substrate
n/a
Meas. Tech.
ChEMBL_2049319 (CHEMBL4704018)
Ki
5.7±n/a nM
Citation
Koralewski, R; Dymek, B; Mazur, M; Sklepkiewicz, P; Olejniczak, S; Czestkowski, W; Matyszewski, K; Andryianau, G; Niedziejko, P; Kowalski, M; Gruza, M; Borek, B; Jedrzejczak, K; Bartoszewicz, A; Pluta, E; Rymaszewska, A; Kania, M; Rejczak, T; Piasecka, S; Mlacki, M; Mazurkiewicz, M; Piotrowicz, M; Salamon, M; Zagozdzon, A; Napiorkowska-Gromadzka, A; Bartlomiejczak, A; Mozga, W; Dobrzański, P; Dzwonek, K; Golab, J; Nowotny, M; Olczak, J; Golebiowski, A Discovery of J Med Chem 63:15527-15540 (2020) [PubMed] Article More Info.:
Target
Name:
Acidic mammalian chitinase
Synonyms:
AMCase | YNL | CHIA_MOUSE | Chia | Chia1
Type:
PROTEIN
Mol. Mass.:
51991.60
Organism:
Mouse
Description:
ChEMBL_828636
Residue:
473
Sequence:
MAKLLLVTGLALLLNAQLGSAYNLICYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQNNEITTIEWNDVTLYKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKEMREAFEQEAIESNRPRLMVTAAVAGGISNIQAGYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSNAYLNVDYVMNYWKNNGAPAEKLIVGFPEYGHTFILRNPSDNGIGAPTSGDGPAGPYTRQAGFWAYYEICTFLRSGATEVWDASQEVPYAYKANEWLGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTSTLNKALGISTEGCTAPDVPSEPVTTPPGSGSGGGSSGGSSGGSGFCADKADGLYPVADDRNAFWQCINGITYQQHCQAGLVFDTSCNCCNWP
Inhibitor
Name:
BDBM50554340
Synonyms:
CHEMBL4788866
Type:
Small organic molecule
Emp. Form.:
C19H27ClN6O
Mol. Mass.:
390.92
SMILES:
C[C@H]1CN([C@H](CO1)Cc2ccc(cc2)Cl)C3CCN(CC3)c4[nH]nc(n4)N
Structure:
