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Target
Programmed cell death 1 ligand/protein 1
Ligand
BDBM50239947
Substrate
n/a
Meas. Tech.
ChEMBL_2051342 (CHEMBL4706041)
IC50
61±n/a nM
Citation
 Cheng, B; Wang, W; Niu, X; Ren, Y; Liu, T; Cao, H; Wang, S; Tu, Y; Chen, J; Liu, S; Yang, X; Chen, J Discovery of Novel and Highly Potent Resorcinol Dibenzyl Ether-Based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment. J Med Chem 63:15946-15959 (2020) [PubMed]  Article 
Target
Name:
Programmed cell death 1 ligand/protein 1
Synonyms:
PD-1/PD-L1 | Programmed cell death protein 1/Programmed cell death 1 ligand 1
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Programmed cell death protein 1
Synonyms:
CD_antigen=CD279 | Programmed cell death protein 1 | Protein PD-1 | hPD-1 | PDCD1_HUMAN | PDCD1 | PD1
Type:
PROTEIN
Mol. Mass.:
31650.07
Organism:
Human
Description:
ChEMBL_108437
Residue:
288
Sequence:
MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
  
Component 2
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | CD_antigen=CD274 | PD-L1 | PDCD1 ligand 1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1 | PD1L1_HUMAN | CD274 | B7H1 | PDCD1L1 | PDCD1LG1 | PDL1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Human
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM50239947
Synonyms:
US9872852, Example 202 | CHEMBL4089730 | US20230303494, Compound BMS202 | US20240043392, Compound BMS-202 | US20240327387, Compound BMS202
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: