Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50555363
Substrate
n/a
Meas. Tech.
ChEMBL_2051751 (CHEMBL4706450)
EC50
20200±n/a nM
Citation
 An, S; Kim, G; Kim, HJ; Ahn, S; Kim, HY; Ko, H; Hyun, YE; Nguyen, M; Jeong, J; Liu, Z; Han, J; Choi, H; Yu, J; Kim, JW; Lee, HW; Jacobson, KA; Cho, WJ; Kim, YM; Kang, KW; Noh, M; Jeong, LS Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators. J Med Chem 63:16012-16027 (2020) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
Peroxisome proliferator-activated receptor delta | PPAR delta | NUCI | Nuclear hormone receptor 1 | NUC1 | Nuclear receptor subfamily 1 group C member 2 | Peroxisome proliferator-activated receptor beta | PPAR-beta | PPARD_HUMAN | PPARD | NR1C2 | PPARB | Peroxisome proliferator-activated receptor
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Human
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50555363
Synonyms:
CHEMBL4758410
Type:
Small organic molecule
Emp. Form.:
C17H17ClIN5O3
Mol. Mass.:
501.71
SMILES:
O[C@@H]1CO[C@@H](Cn2cnc3c(NCc4cccc(I)c4)nc(Cl)nc23)[C@@H]1O |r|
Structure:
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