Target
Acid ceramidase
Ligand
BDBM50556791
Substrate
n/a
Meas. Tech.
ChEMBL_2057391 (CHEMBL4712392)
IC50
14±n/a nM
Citation
 Caputo, SDi Martino, SCilibrasi, VTardia, PMazzonna, MRusso, DPenna, ISumma, MBertozzi, SMRealini, NMargaroli, NMigliore, MOttonello, GLiu, MLansbury, PArmirotti, ABertorelli, RRay, SSSkerlj, RScarpelli, R Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors. J Med Chem 63:15821-15851 (2020) [PubMed]  Article 
Target
Name:
Acid ceramidase
Synonyms:
ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC)
Type:
Enzyme
Mol. Mass.:
44662.65
Organism:
Homo sapiens (Human)
Description:
Q13510
Residue:
395
Sequence:
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
  
Inhibitor
Name:
BDBM50556791
Synonyms:
CHEMBL4754069
Type:
Small organic molecule
Emp. Form.:
C12H18F3N3O
Mol. Mass.:
277.286
SMILES:
CCCCCCNC(=O)n1nc(C)cc1C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: