Target
Growth factor receptor-bound protein 2
Ligand
BDBM50122796
Substrate
n/a
Meas. Tech.
ChEMBL_72358 (CHEMBL686445)
IC50
2±n/a nM
Citation
 Wei, CQGao, YLee, KGuo, RLi, BZhang, MYang, DBurke, TR Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems. J Med Chem 46:244-54 (2003) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50122796
Synonyms:
CHEMBL84798 | [18-Carbamoylmethyl-14-(2,3-dihydro-naphthalen-1-ylmethyl)-8,17,20-trioxo-10-(4-phosphonomethyl-phenyl)-7,16,19-triaza-spiro[5.14]icos-11-en-9-yl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C39H49N4O9P
Mol. Mass.:
748.8015
SMILES:
NC(=O)C[C@@H]1NC(=O)C2(CCCCC2)NC(=O)[C@@H](CC(O)=O)[C@H](\C=C\C[C@@H](CC2=c3ccccc3=CCC2)CNC1=O)c1ccc(CP(O)(O)=O)cc1 |c:29,36,t:24|
Structure:
Search PDB for entries with ligand similarity: