Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50122792
Substrate
n/a
Meas. Tech.
ChEMBL_72358 (CHEMBL686445)
IC50
8±n/a nM
Citation
 Wei, CQ; Gao, Y; Lee, K; Guo, R; Li, B; Zhang, M; Yang, D; Burke, TR Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems. J Med Chem 46:244-54 (2003) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50122792
Synonyms:
CHEMBL312875 | [3-Carbamoylmethyl-14-(2,3-dihydro-naphthalen-1-ylmethyl)-6,6-dimethyl-2,5,8-trioxo-10-(4-phosphonomethyl-phenyl)-1,4,7triaza-cyclopentadec-11-en-9-yl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C36H45N4O9P
Mol. Mass.:
708.7377
SMILES:
CC1(C)NC(=O)[C@@H](CC(O)=O)[C@H](\C=C\C[C@@H](CC2=c3ccccc3=CCC2)CNC(=O)[C@H](CC(N)=O)NC1=O)c1ccc(CP(O)(O)=O)cc1 |c:17,24,t:12|
Structure:
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