Reaction Details Report a problem with these data
Target
Arginase-1
Ligand
BDBM50230418
Substrate
n/a
Meas. Tech.
ChEMBL_2074193 (CHEMBL4729727)
Kd
3600±n/a nM
Citation
 Borek, B; Gajda, T; Golebiowski, A; Blaszczyk, R Boronic acid-based arginase inhibitors in cancer immunotherapy. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Arginase-1
Synonyms:
Liver-type arginase | Type I arginase | ARGI1_HUMAN | ARG1
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Human
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM50230418
Synonyms:
N-OMEGA-HYDROXY-L-ARGININE | Nomega-hydroxy-L-arginine | N(gamma)-hydroxy-L-arginine | CHEMBL260629
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
NC(NO)=NCCC[C@H]([NH3+])C([O-])=O |r,w:4.4|
Structure:
Search PDB for entries with ligand similarity: