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Target
Arginase-2, mitochondrial
Ligand
BDBM50561039
Substrate
n/a
Meas. Tech.
ChEMBL_2074202 (CHEMBL4729736)
IC50
10.0±n/a nM
Citation
 Borek, B; Gajda, T; Golebiowski, A; Blaszczyk, R Boronic acid-based arginase inhibitors in cancer immunotherapy. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Arginase-2, mitochondrial
Synonyms:
Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase | ARGI2_HUMAN | ARG2
Type:
PROTEIN
Mol. Mass.:
38576.93
Organism:
Human
Description:
ChEMBL_978892
Residue:
354
Sequence:
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
  
Inhibitor
Name:
BDBM50561039
Synonyms:
CHEMBL4749355 | US11420984, Example 23
Type:
Small organic molecule
Emp. Form.:
C10H21BN2O4
Mol. Mass.:
244.10
SMILES:
CN[C@H]1CN[C@](CCCCB(O)O)(C1)C(O)=O |r|
Structure:
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