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Target
26S proteasome regulatory subunit 6B
Ligand
BDBM50562860
Substrate
n/a
Meas. Tech.
ChEMBL_2080788 (CHEMBL4736579)
IC50
75000±n/a nM
Citation
 Zhang, G; Li, S; Wang, F; Jones, AC; Goldberg, AFG; Lin, B; Virgil, S; Stoltz, BM; Deshaies, RJ; Chou, TF A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells. Eur J Med Chem 213:0 (2021) [PubMed]  Article 
Target
Name:
26S proteasome regulatory subunit 6B
Synonyms:
PRS6B_HUMAN | PSMC4 | MIP224 | TBP7 | 26S proteasome AAA-ATPase subunit RPT3 | 26S proteasome regulatory subunit 6B | MB67-interacting protein
Type:
PROTEIN
Mol. Mass.:
47353.09
Organism:
Human
Description:
ChEMBL_106197
Residue:
418
Sequence:
MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
  
Inhibitor
Name:
BDBM50562860
Synonyms:
CHEMBL4762311
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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