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Target
Vitamin D3 receptor
Ligand
BDBM50565949
Substrate
n/a
Meas. Tech.
ChEMBL_2094256 (CHEMBL4775519)
EC50
0.240±n/a nM
Citation
 Sasaki, H; Masuno, H; Kawasaki, H; Yoshihara, A; Numoto, N; Ito, N; Ishida, H; Yamamoto, K; Hirata, N; Kanda, Y; Kawachi, E; Kagechika, H; Tanatani, A Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists. J Med Chem 64:516-526 (2021) [PubMed]  Article 
Target
Name:
Vitamin D3 receptor
Synonyms:
1,25-dihydroxyvitamin D3 receptor | Nuclear receptor subfamily 1 group I member 1 | Retinoic acid receptor RXR-alpha/Vitamin D3 receptor | VDR_HUMAN | VDR | NR1I1
Type:
Protein
Mol. Mass.:
48288.72
Organism:
Human
Description:
P11473
Residue:
427
Sequence:
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS
  
Inhibitor
Name:
BDBM50565949
Synonyms:
CHEMBL4794075
Type:
Small organic molecule
Emp. Form.:
C28H48O3
Mol. Mass.:
432.69
SMILES:
C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@@H](C4)CC(C)(C)O)C)C
Structure:
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