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Target
Retinoic acid receptor, gamma
Ligand
BDBM50133125
Substrate
n/a
Meas. Tech.
ChEMBL_196168 (CHEMBL705564)
Ki
1109±n/a nM
Citation
 Michellys, PY; Ardecky, RJ; Chen, JH; D'Arrigo, J; Grese, TA; Karanewsky, DS; Leibowitz, MD; Liu, S; Mais, DA; Mapes, CM; Montrose-Rafizadeh, C; Ogilvie, KM; Reifel-Miller, A; Rungta, D; Thompson, AW; Tyhonas, JS; Boehm, MF Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. J Med Chem 46:4087-103 (2003) [PubMed]  Article  BDB Entry
Target
Name:
Retinoic acid receptor, gamma
Synonyms:
Retinoic acid receptor gamma
Type:
PROTEIN
Mol. Mass.:
53686.83
Organism:
Rattus norvegicus
Description:
ChEMBL_196168
Residue:
485
Sequence:
MLALPLPPPGAGHCGGRRGNGLRVLGVLAPSFSPSRVAMYDCMESFVPGPRRLYGAAGPGAGLLRRATGSSCFAGLESFAWAQPASLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGPPDNYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSKPGPHPKASSEDEAPGSQGKRGQSPQPDQGP
  
Inhibitor
Name:
BDBM50133125
Synonyms:
5-{3-[3,5-Diisopropyl-2-(2,2,2-trifluoro-ethoxy)-phenyl]-pyridin-4-yl}-3-methyl-penta-2,4-dienoic acid | CHEMBL130577
Type:
Small organic molecule
Emp. Form.:
C25H28F3NO3
Mol. Mass.:
447.4899
SMILES:
CC(C)c1cc(C(C)C)c(OCC(F)(F)F)c(c1)-c1cnccc1\C=C\C(\C)=C\C(O)=O
Structure:
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