Reaction Details Report a problem with these data
Target
Retinoic acid receptor RXR-gamma
Ligand
BDBM50141599
Substrate
n/a
Meas. Tech.
ChEBML_196589
Ki
>10000±n/a nM
Citation
 Michellys, PY; D'Arrigo, J; Grese, TA; Karanewsky, DS; Leibowitz, MD; Mais, DA; Mapes, CM; Reifel-Miller, A; Rungta, D; Boehm, MF Design, synthesis and structure-activity relationship of novel RXR-selective modulators. Bioorg Med Chem Lett 14:1593-8 (2004) [PubMed]  Article  BDB Entry
Target
Name:
Retinoic acid receptor RXR-gamma
Synonyms:
Retinoid X receptor gamma
Type:
PROTEIN
Mol. Mass.:
50900.28
Organism:
Mus musculus
Description:
ChEMBL_196589
Residue:
463
Sequence:
MYGNYSHFMKFPTGFGGSPGHTGSTSMSPSVALPTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECASSSHEDMPVERILEAELAVEPKTESYGDMNVENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDSFLMEMLETPLQIT
  
Inhibitor
Name:
BDBM50141599
Synonyms:
(E)-3-{4-[3,5-Di-tert-butyl-2-(2,2,2-trifluoro-ethoxy)-phenyl]-benzo[b]thiophen-2-yl}-but-2-enoic acid | CHEMBL41260
Type:
Small organic molecule
Emp. Form.:
C28H31F3O3S
Mol. Mass.:
504.604
SMILES:
C\C(=C/C(O)=O)c1cc2c(cccc2s1)-c1cc(cc(c1OCC(F)(F)F)C(C)(C)C)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: