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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50143944
Substrate
n/a
Meas. Tech.
ChEMBL_72357 (CHEMBL686444)
IC50
12.1±n/a nM
Citation
 Shi, ZD; Wei, CQ; Lee, K; Liu, H; Zhang, M; Araki, T; Roberts, LR; Worthy, KM; Fisher, RJ; Neel, BG; Kelley, JA; Yang, D; Burke, TR Macrocyclization in the design of non-phosphorus-containing Grb2 SH2 domain-binding ligands. J Med Chem 47:2166-9 (2004) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50143944
Synonyms:
2-[4-((E)-(9S,10S,14S,18S)-18-Carbamoylmethyl-9-carboxymethyl-14-naphthalen-1-ylmethyl-8,17,20-trioxo-7,16,19-triaza-spiro[5.14]icos-11-en-10-yl)-phenyl]-malonate;disodium | CHEMBL70024
Type:
Small organic molecule
Emp. Form.:
C41H44N4O10
Mol. Mass.:
752.81
SMILES:
NC(=O)C[C@@H]1NC(=O)C2(CCCCC2)NC(=O)[C@@H](CC(O)=O)[C@H](\C=C\C[C@@H](Cc2cccc3ccccc23)CNC1=O)c1ccc(cc1)C(C([O-])=O)C([O-])=O |t:24|
Structure:
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