Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM349368
Substrate
n/a
Meas. Tech.
ChEMBL_2130287 (CHEMBL4839716)
Ki
0.440000±n/a nM
Citation
 Rishton, GM; Look, GC; Ni, ZJ; Zhang, J; Wang, Y; Huang, Y; Wu, X; Izzo, NJ; LaBarbera, KM; Limegrover, CS; Rehak, C; Yurko, R; Catalano, SM Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease. ACS Med Chem Lett 12:1389-1395 (2021) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
Meningioma-associated protein 30 | Sigma-2 receptor | Sigma2 receptor | Transmembrane protein 97 | SGMR2_HUMAN | TMEM97 | MAC30 | S2R
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Human
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM349368
Synonyms:
US10207991, Ex. Cpd. No. 11 | US10611728, Example Compound 11 | US11691947, Example 11
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1cc2CN(Cc2cc1OC)[C@H](C)CCc1ccc(Cl)c(Cl)c1 |r|
Structure:
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