Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM50151229
Substrate
n/a
Meas. Tech.
ChEMBL_306707
IC50
21±n/a nM
Citation
 Cavasotto, CNLiu, GJames, SYHobbs, PDPeterson, VJBhattacharya, AAKolluri, SKZhang, XKLeid, MAbagyan, RLiddington, RCDawson, MI Determinants of retinoid X receptor transcriptional antagonism. J Med Chem 47:4360-72 (2004) [PubMed]  Article
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Inhibitor
Name:
BDBM50151229
Synonyms:
4-[Cyclopropylidene-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid | CHEMBL277626
Type:
Small organic molecule
Emp. Form.:
C26H30O2
Mol. Mass.:
374.5152
SMILES:
[#6]-c1cc2c(cc1\[#6](=[#6]-1\[#6]-[#6]-1)-c1ccc(cc1)-[#6](-[#8])=O)C([#6])([#6])[#6]-[#6]C2([#6])[#6]
Structure:
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