Target
Flap endonuclease 1
Ligand
BDBM50152554
Substrate
n/a
Meas. Tech.
ChEMBL_304758
IC50
3510±n/a nM
Citation
 Tumey, LNHuck, BGleason, EWang, JSilver, DBrunden, KBoozer, SRundlett, SSherf, BMurphy, SBailey, ADent, TLeventhal, CHarrington, JBennani, YL The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors. Bioorg Med Chem Lett 14:4915-8 (2004) [PubMed]  Article
Target
Name:
Flap endonuclease 1
Synonyms:
DNase IV | FEN-1 | FEN1 | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:
PROTEIN
Mol. Mass.:
42602.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517026
Residue:
380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSTKKKAKTGAAGKFKRGK
  
Inhibitor
Name:
BDBM50152554
Synonyms:
4-(2-Chloro-phenyl)-2,4-dioxo-butyric acid | CHEMBL363721 | Sacchettini_3
Type:
Small organic molecule
Emp. Form.:
C10H7ClO4
Mol. Mass.:
226.613
SMILES:
OC(=O)C(=O)CC(=O)c1ccccc1Cl
Structure:
Search PDB for entries with ligand similarity: