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Target
Baculoviral IAP repeat-containing protein 3
Ligand
BDBM50588298
Substrate
n/a
Meas. Tech.
ChEMBL_2186652 (CHEMBL5098734)
IC50
32±n/a nM
Citation
 Udompholkul, P; Baggio, C; Gambini, L; Alboreggia, G; Pellecchia, M Lysine Covalent Antagonists of Melanoma Inhibitors of Apoptosis Protein. J Med Chem 64:16147-16158 (2021) [PubMed] 
Target
Name:
Baculoviral IAP repeat-containing protein 3
Synonyms:
Baculoviral IAP repeat-containing protein 3 | Inhibitor of apoptosis protein 3 (cIAP2) | cIAP1/cIAP2 | BIRC3_HUMAN | BIRC3 | API2 | MIHC | RNF49 | Baculoviral IAP repeat-containing protein 3 (IAP1 BIR3) | XIAP-BIR3
Type:
Protein
Mol. Mass.:
68365.75
Organism:
Human
Description:
Q13489
Residue:
604
Sequence:
MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS
  
Inhibitor
Name:
BDBM50588298
Synonyms:
CHEMBL5174454
Type:
Small organic molecule
Emp. Form.:
C29H36FN5O7S
Mol. Mass.:
617.70
SMILES:
CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(ccc1OC)S(F)(=O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1CCc2ccccc12 |r|
Structure:
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