Reaction Details
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Excitatory amino acid transporter 2
Ligand
BDBM50592916
Substrate
n/a
Meas. Tech.
ChEMBL_2206405 (CHEMBL5119113)
EC50
25±n/a nM
Citation
Abram, M; Jakubiec, M; Reeb, K; Cheng, MH; Gedschold, R; Rapacz, A; Mogilski, S; Socała, K; Nieoczym, D; Szafarz, M; Latacz, G; Szulczyk, B; Kalinowska-Tłuścik, J; Gawel, K; Esguerra, CV; Wyska, E; Müller, CE; Bahar, I; Fontana, ACK; Wlaź, P; Kamiński, RM; Kamiński, K Discovery of ( J Med Chem 65:11703-11725 (2022) [PubMed] More Info.:
Target
Name:
Excitatory amino acid transporter 2
Synonyms:
Solute carrier family 1 member 2 | Glutamate/aspartate transporter II | Sodium-dependent glutamate/aspartate transporter 2 | EAA2_HUMAN | SLC1A2 | EAAT2 | GLT1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
62103.57
Organism:
Human
Description:
Excitatory Amino Acid EAAT2 0 0::P43004
Residue:
574
Sequence:
MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYAAHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
Inhibitor
Name:
BDBM50592916
Synonyms:
CHEMBL5206486
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
