Reaction Details Report a problem with these data
Target
Appetite-regulating hormone
Ligand
BDBM50517283
Substrate
n/a
Meas. Tech.
ChEMBL_2207823 (CHEMBL5120531)
IC50
2.2±n/a nM
Citation
 Li, HZ; Shao, XX; Shou, LL; Li, N; Liu, YL; Xu, ZG; Guo, ZY Development of Esterase-Resistant and Highly Active Ghrelin Analogs via Thiol-Ene Click Chemistry. ACS Med Chem Lett 13:1655-1662 (2022) [PubMed] 
Target
Name:
Appetite-regulating hormone
Synonyms:
Growth hormone secretagogue | Motilin-related peptide | Protein M46 | Ghrelin | Ghrelin-27 | Ghrelin-28 | Growth hormone-releasing peptide | Obestatin | GHRL_HUMAN | GHRL | MTLRP
Type:
PROTEIN
Mol. Mass.:
12908.57
Organism:
Human
Description:
ChEMBL_790253
Residue:
117
Sequence:
MPSPGTVCSLLLLGMLWLDLAMAGSSFLSPEHQRVQQRKESKKPPAKLQPRALAGWLRPEDGGQAEGAEDELEVRFNAPFDVGIKLSGVQYQQHSQALGKFLQDILWEEAKEAPADK
  
Inhibitor
Name:
BDBM50517283
Synonyms:
CHEMBL425281
Type:
Small organic molecule
Emp. Form.:
C149H249N47O42
Mol. Mass.:
3370.92
SMILES:
CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r|
Structure:
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