Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50166551
Substrate
n/a
Meas. Tech.
ChEMBL_306643 (CHEMBL832980)
IC50
3000±n/a nM
Citation
 Kanuma, K; Omodera, K; Nishiguchi, M; Funakoshi, T; Chaki, S; Semple, G; Tran, TA; Kramer, B; Hsu, D; Casper, M; Thomsen, B; Beeley, N; Sekiguchi, Y Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett 15:2565-9 (2005) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPYY5 | Y5 receptor | NPY-Y5 | NPY5-R | NPY-Y5 receptor | NPY5R_HUMAN | NPY5R | NPYR5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5)
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Human
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50166551
Synonyms:
N*2*-[1-(4-Bromo-2-trifluoromethoxy-benzenesulfonyl)-piperidin-4-ylmethyl]-N*4*,N*4*-dimethyl-quinazoline-2,4-diamine | CHEMBL194173
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CN(C)c1nc(NCC2CCN(CC2)S(=O)(=O)c2ccc(Br)cc2OC(F)(F)F)nc2ccccc12
Structure:
Search PDB for entries with ligand similarity: