Target
Growth factor receptor-bound protein 2
Ligand
BDBM50168318
Substrate
n/a
Meas. Tech.
ChEMBL_305462 (CHEMBL830958)
IC50
6.3±n/a nM
Citation
 Kang, SUShi, ZDWorthy, KMBindu, LKDharmawardana, PGChoyke, SJBottaro, DPFisher, RJBurke, TR Examination of phosphoryl-mimicking functionalities within a macrocyclic Grb2 SH2 domain-binding platform. J Med Chem 48:3945-8 (2005) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50168318
Synonyms:
CHEMBL424823 | [(15R,20S)-18-Carbamoylmethyl-10-[4-(hydroxy-methyl-phosphinoylmethyl)-phenyl]-14-(5-methyl-indol-1-ylmethyl)-20-oxo-8,17-di(S)-oxo-7,16,19-triaza-spiro[5.14]icos-11-en-9-yl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C39H50N5O8P
Mol. Mass.:
747.8168
SMILES:
Cc1ccc2n(C[C@H]3CNC(=O)[C@H](CC(N)=O)NC(=O)C4(CCCCC4)NC(=O)[C@@H](CC(O)=O)[C@H](\C=C\C3)c3ccc(CP(C)(O)=O)cc3)ccc2c1 |t:36|
Structure:
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