Reaction Details Report a problem with these data
Target
Nuclear factor erythroid 2-related factor 2
Ligand
BDBM50596392
Substrate
n/a
Meas. Tech.
ChEMBL_2220399 (CHEMBL5133733)
EC50
2900±n/a nM
Citation
 Huang, W; Huang, Y; Cui, J; Wu, Y; Zhu, F; Huang, J; Ma, L Design and synthesis of Osthole-based compounds as potential Nrf2 agonists. Bioorg Med Chem Lett 61:0 (2022) [PubMed] 
Target
Name:
Nuclear factor erythroid 2-related factor 2
Synonyms:
HEBP1 | NF-E2-related factor 2 | NFE2-related factor 2 | Nuclear factor, erythroid derived 2, like 2 | Kelch-like ECH-associated protein 1 | Nuclear factor erythroid 2-related factor 2 | NF2L2_HUMAN | NFE2L2 | NRF2
Type:
PROTEIN
Mol. Mass.:
67786.89
Organism:
Human
Description:
ChEMBL_107924
Residue:
605
Sequence:
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCMQLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDVKKN
  
Inhibitor
Name:
BDBM50596392
Synonyms:
CHEMBL5174881
Type:
Small organic molecule
Emp. Form.:
C20H17BrO3
Mol. Mass.:
385.26
SMILES:
CC1(C)CCc2c(O1)c(Br)cc1cc(-c3ccccc3)c(=O)oc21
Structure:
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