Reaction Details Report a problem with these data
Target
Retinoic acid receptor RXR-beta
Ligand
BDBM50179115
Substrate
n/a
Meas. Tech.
ChEMBL_349698 (CHEMBL866289)
EC50
98±n/a nM
Citation
 Farmer, LJ; Marron, KS; Canan Koch, SS; Hwang, CK; Kallel, EA; Zhi, L; Nadzan, AM; Robertson, DW; Bennani, YL Aza-retinoids as novel retinoid X receptor-specific agonists. Bioorg Med Chem Lett 16:2352-6 (2006) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-beta
Synonyms:
NR2B2 | Nuclear receptor subfamily 2 group B member 2 | RXRB | RXRB_HUMAN | Retinoic acid receptor RXR-beta | Retinoid X receptor beta | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
56932.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_39045
Residue:
533
Sequence:
MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQTPEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
  
Inhibitor
Name:
BDBM50179115
Synonyms:
(2E,4E)-6-((6-tert-butyl-1,1-dimethyl-2,3-dihydro-1H-inden-4-yl)(cyclopropylmethyl)amino)-3-methylhexa-2,4-dienoic acid | CHEMBL377178
Type:
Small organic molecule
Emp. Form.:
C26H37NO2
Mol. Mass.:
395.5775
SMILES:
C\C(\C=C\CN(CC1CC1)c1cc(cc2c1CCC2(C)C)C(C)(C)C)=C/C(O)=O
Structure:
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