Reaction Details Report a problem with these data
Target
Potassium voltage-gated channel subfamily A member 2
Ligand
BDBM50182587
Substrate
n/a
Meas. Tech.
ChEMBL_334898 (CHEMBL861276)
EC50
2500±n/a nM
Citation
 Harvey, AJ; Baell, JB; Toovey, N; Homerick, D; Wulff, H A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone. J Med Chem 49:1433-41 (2006) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 2
Synonyms:
HBK5 | HUKIV | NGK1 | Potassium voltage-gated channel subfamily A member 2 | Voltage-gated potassium channel subunit Kv1.2 | KCNA2_HUMAN | KCNA2 | Voltage-gated potassium channel
Type:
PROTEIN
Mol. Mass.:
56695.97
Organism:
Human
Description:
ChEMBL_334898
Residue:
499
Sequence:
MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV
  
Inhibitor
Name:
BDBM50182587
Synonyms:
5-acetyl-4-(4'-chloro)benzyloxy-6-hydroxy-7-methoxybenzofuran | CHEMBL382154
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1c(O)c(C(C)=O)c(OCc2ccc(Cl)cc2)c2ccoc12
Structure:
Search PDB for entries with ligand similarity: