Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein
Ligand
BDBM50605474
Substrate
n/a
Meas. Tech.
ChEMBL_2251793 (CHEMBL5166003)
IC50
76±n/a nM
Citation
 Liu, J; Yuan, L; Ruan, Y; Deng, B; Yang, Z; Ren, Y; Li, L; Liu, T; Zhao, H; Mai, R; Chen, J Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy. J Med Chem 65:6593-6611 (2022) [PubMed] 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
Mediator of IRF3 activation | Transmembrane protein 173 | Endoplasmic reticulum interferon stimulator | Synonyms=ERIS | hSTING | hMITA | STING_HUMAN | STING1 | ERIS | MITA | STING | TMEM173
Type:
Protein
Mol. Mass.:
42215.19
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM50605474
Synonyms:
CHEMBL5189857
Type:
Small organic molecule
Emp. Form.:
C25H19FN2O4S
Mol. Mass.:
462.50
SMILES:
Oc1ccc(NC(=O)c2ccc(cc2)-c2ccccc2)cc1NS(=O)(=O)c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: